Additionally, it has been proposed that Trop-2, via the PI3K/AKT and MAPK pathways, influences the tumor microenvironment by promoting the polarization of macrophages toward the M2 phenotype, which is linked to tumor-promoting processes, such as tissue remodeling, angiogenesis, and immune suppression [28,30,31]. This evidence concerns the gene TACSTD2 and neoplasm.