The IL-6 and IL-8 biomarkers have previously been reported to have the next best predictive ability for sepsis after PCT (Harbarth et al., 2001 [35]), in line with a systematic investigation approving the usefulness of IL6 and IL8 as sepsis markers (Hou et al., 2015 [12]; Matsumoto et al., 2018 [13]). Here, CALCA is linked to Sepsis.