On the other hand, CRP values were found to significantly increase the risk of all evaluated composite outcomes, and the calculated effect could have a clinical significance only on the occurrence of composite outcome 1 (Apgar score < 7 at 1 min of birth + respiratory distress syndrome + non-invasive ventilation) and 2 (Apgar score < 7 at 1 min of birth + respiratory distress syndrome + metabolic acidosis). This evidence concerns the gene CRP and metabolic acidosis.