The absence of a correlation between the severity and extent of CAD, as assessed by CACS, and the levels of CTRP and chemerin in our study may be attributed to the limitations of the CACS method in detecting non-calcified atherosclerotic plaques during the early stages of atherosclerosis, where elevated levels of adipokines are anticipated [17,25,26,31,43,44]. The gene discussed is RARRES2; the disease is coronary artery disorder.