Contrary to previous studies that identified a correlation between CAD severity and extent, as measured by the Gensini Score, SYNTAX score, or the number of coronary arteries with critical stenosis, and serum levels of CTRP5 or chemerin derived from ICA method data [17,31,43,44], our research did not find a relationship between CACS, a marker of CAD severity and extent [27,28,29], and serum concentrations of CTRP5 and chemerin. This evidence concerns the gene RARRES2 and coronary artery disorder.