Although the number of cases in our study on the tumor mutation profile and tumor microenvironment in colorectal cancers was limited, significant results were still obtained in terms of addressing HIF-1α, LOX and ITGA5 expression in the tumor microenvironment and histopathological and clinical prognostic parameters in a broad framework and identifying significant relationship with progression-free survival risk, likely reflecting hypoxia-driven resistance mechanisms. This evidence concerns the gene HIF1A and neoplasm.