More comprehensive studies examining the relationship between HIF-1α, LOX and ITGA5 proteins expressed in the tumor microenvironment/stroma or molecules that may have potential biomarker and targetable properties, as well as the molecular and genetic features of the tumor microenvironment, will contribute to the clarification of the biological behavior of the tumor, thus guiding the development of the treatments or alternatives. This evidence concerns the gene HIF1A and neoplasm.