GLA and Nager acrofacial dysostosis: Anderson–Fabry disease (AFD) is a rare X-linked lysosomal storage disorder caused by variants in the GLA gene, leading to a deficiency of the enzyme α-galactosidase A. This enzymatic deficit results in the accumulation of globotriaosylceramide (Gb3) in various tissues, including the heart, kidneys, and nervous system.