PTCH1 and neoplasm: Moreover, the RAB8A-shRNA-expressing tumor group also showed weakened staining of GLI1 and PTCH1 (Fig. 7N) as well as the downregulated protein expression of GLI1 and PTCH1 (Fig. 7O), which was in contrast to the positive effects of RAB8A-ovexpression on xenograft growth and GLI1 expression in HO8910-derived tumors cells (Fig. 4H-K).