OPTN and colorectal cancer: For example, binding of Formin homology protein interacting protein 2 (FIP2) to RAB11 promotes epithelial-mesenchymal transition (EMT) and metastasis in gastric cancer [58], and this complex also potentiates colorectal cancer cells migration and invasion by inducing MMP-7 expression through activating the PI3K/AKT signaling [59].