Consistently, compared with the HO8910 cells infected with control viruses, the RAB8A-overexpressing lentiviruses-infected HO8910 cells resulted in the xenografts with the significantly increased tumor weight and tumor volume in nude mice (Fig. 4H-J), and the protein expression of GLI1 was markedly induced in corresponding tumor tissues where RAB8A was ectopicly expressed (Fig. 4K). Here, GLI1 is linked to neoplasm.