GLI1 and cancer: Consistently, the enrichment analysis of the top 20 pathways from KEGG also exhibited that RAB8A was correlated with multiple pathways in cancer, including the Hedgehog (HH) signaling pathway (Fig. 4E), based on which and in combination with the heat-map data showing marked increase of GLI1 expression (Figure S2A), a target in HH signaling, we finally selected the HH signaling as a potential candidate.