Compared with the corresponding control SK-OV-3 cells and A2780 cells that carried a scrambled shRNA sequence, the GPR137-shRNA lentiviruses-infected SK-OV-3 cells resulted in the xenografts with the significantly decreased tumor weight and tumor volume in nude mice (Fig. 7A,B,D,H), and the RAB8A-low expressing A2780 cells consistently revealed the decreased ovarian tumor weight in a mouse model of in situ serous ovarian cancer (Fig. 7E,F,I). The gene discussed is RAB8A; the disease is ovarian neoplasm.