AAV-CLDN11-OE mice with obesity-related SAP (FS + AAV-CLDN11-OE) had lower levels of serum D-lactate (Fig. 2B) and endotoxin (Fig. 2C) than AAV-control mice with obesity-related SAP (FS + AAV-control). Here, CLDN11 is linked to obesity due to melanocortin 4 receptor deficiency.