Long noncoding RNA (lncRNA) such as metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) (Tian et al. 2023) and DNA methylation–deregulated and RNA m6A reader–cooperating lncRNA (DMDRMR) (Gu et al. 2021) directly bound with IGF2BP3 protein and regulated its expression in diabetic retinopathy and clear cell renal cell carcinoma, respectively. The gene discussed is MALAT1; the disease is diabetic retinopathy.