Increased CUL4A and CUL4B expression has been observed in neoplastic contexts in humans and mice,46, 61 for example, increased activity of CRL4B has been linked to epigenetic silencing of the tumour suppressor gene IGFBP3 in vitro and in vivo62 and CRL4A hyperactivity has been shown to facilitate chemoresistance in multiple cancer contexts, notably in cisplatin‐resistant ovarian cancers.37, 63, 64. This evidence concerns the gene CUL4A and cancer.