Importantly, additional evidence supports and highlights the importance of TRPC channels as a critical regulator of calcium signaling in podocytes: ANG II activates ROCE to induce TRPC6-mediated Ca2+ influx in podocytes under hyperglycemic condition modelling diabetes [28], ANG II-induced albuminuria is reduced in TRPC6 knockout mice [29] and the inhibition of ANGII by losartan blocks calcium signaling in podocytes [6]. This evidence concerns the gene AGT and diabetes mellitus.