TNFSF11 and systemic lupus erythematosus: OPG decreased in both strains.<h4>Conclusion</h4>Both glucocorticoids and SLE contribute to abnormal bone remodeling through RANKL/OPG pathway.<h4>Impact</h4>Glucocorticoid (GC) treatment in a mouse model of systemic lupus erythematosus (SLE) leads to significant changes in bone parameters, including decreased bone mineral density (BMD) and alterations in bone structure.