COL6A3 and coronary artery disorder: Notably, the C-terminal-binding aptamer (Fig. 5b) increased the risk of CAD (OR = 1.47 per standard deviation increase in the protein level, 95% CI: 1.26–1.70, P = 4.5 × 10−8), whereas the N-terminal-binding aptamer (that is, the non-cleaved portion of COL6A3) did not (OR = 1.00, 95% CI: 0.87–1.14, P = 0.98) in domain-aware MR (Fig. 5c and Supplementary Table 13).