We found that fat mass independently increased plasma levels of all protein mediators (COL6A3-derived endotrophin, F11, PCSK9, C1R and SPATA20) (Fig. 8a and Supplementary Table 18) and increased the odds of type 2 diabetes, CAD and ischemic stroke (Supplementary Table 19). Here, SPATA20 is linked to type 2 diabetes mellitus.