COL6A3 and coronary artery disorder: In addition, sex-stratified Cox regression analysis for cumulative incidents of CAD in the UK Biobank showed that a standard deviation increase in plasma C-terminal COL6A3 levels was associated with an increased cumulative incidence of CAD in both females (HR = 1.15, 95% CI: 1.07–1.23, P = 6.5 × 10−5) and males (HR = 1.24, 95% CI: 1.18–1.30, P < 2.2 × 10−16).