MR showed that a standard deviation increase in C-terminal COL6A3 levels strongly increased the odds of CAD (OR = 1.30, 95% CI: 1.17–1.45, P = 2.4 × 10−6) (Supplementary Table 13), supported by colocalization (Extended Data Fig. 2). The gene discussed is COL6A3; the disease is coronary artery disorder.