Specifically, we found that each standard deviation increase in C-terminal COL6A3 increased the odds of CAD in the UK Biobank31 (OR = 1.30, 95% CI: 1.17–1.45, P = 2.4 × 10−6), Fenland (OR = 1.23, 95% CI: 1.12–1.35, P = 8.8 × 10−6) and ARIC (OR = 1.09, 95% CI: 1.05–1.13, P = 1.6 × 10−5) data. The gene discussed is COL6A3; the disease is coronary artery disorder.