This subset included several genes previously implicated in melanoma or tumor malignancy more broadly, such as SOX10, whose downregulation leads to elevated EGFR and PDGF receptor signals and increased resistance to BRAF inhibition9; MIA, which is involved in melanocyte lineage and melanoma development42,43; and ERBB3, which can reactivate MAPK upon MEK inhibition through a feedback mechanism44,45. Here, BRAF is linked to melanoma.