Conversely, as in the case of viral infections, we do not expect the SLC15A4-TASL complex to be involved in TLR7/9- and IRF5-independent autoinflammatory and autoimmune models, such as the lupus-like manifestations observed upon TREX1-deficiency which relies on the STING pathway60,61. The gene discussed is IRF5; the disease is systemic lupus erythematosus.