DHODH and neoplasm: Dihydroorotate dehydrogenase (DHODH), which is located at the inner mitochondrial membranes, reduces CoQ to ubiquinol, thereby scavenging phospholipid radicals and preventing ferroptosis in tumor cells, Conversely, its inhibitor brequinar has been demonstrated to suppress the growth of GPX4low tumor cells through the induction of ferroptosis [50].