TNF and neoplasm: Moreover, given that whole-tumor cell lysates can include total potential antigens, whole-tumor cell lysate-based vaccines have been developed.245 Heat shock protein 27 and HPV-16 E7 are transduced into TC-1 cells to develop a tumor cell lysate-based vaccine, which has shown potential for suppressing tumor growth and secreting cytokines such as IFN-γ and TNF-α.246