MAGI1 and cancer: E6 regulates tumor invasion via binding to proteins containing the PDZ motif.106 Research has confirmed that PBM of HPV-16 contributes to the migration and invasion of cancer cells.139 The Scribble complex, the Crumbs complex, and the Par complex, all of which possess a PDZ motif, play pivotal roles in maintaining cellular polarity.140 Membrane-associated guanylate kinase 1 (MAGI1) can serve as a tumor suppressor in the progression of cancer.