The E6 of hr-HPVs can suppress SET7-mediated methylation of p53 and downregulate histone methylation mediated by p53 coactivators, decreasing the binding of p53 to chromatin and transactivation of p53.54 E6 inhibits acetylation of p53 and nucleosomal core histones mediated by p300, which disrupts the activation of genes targeted by p53 and causes the development of cancers.55,56. The gene discussed is TP53; the disease is cancer.