MAPK8 and cancer: For example, Bozkurt et al found that TRAIL can initiate entosis in colon cancer to eliminate cancer cells.[50] TRAIL is also known to induce apoptosis of cancer cells in CRC.[51,52] Besides, it has been found that platelets can promote CRC via PSGL-1/JNK/STAT1 signaling pathway.[53] However, TRAIL can promote platelet apoptosis to inhibit the cell invasion of CRC.[54]