Specifically, the IVW method for genetic prediction revealed that CRC were not associated with CX3CL1 (β = −0.02; 95% CI: −0.07 to 0.02; P = 3.23 × 10-1), GDNF (β = -0.02; 95% CI: −0.06 to 0.02; P = 3.18 × 10-1), IL-2RB (β = 0.00; 95% CI: −0.04 to 0.04; P = 8.78 × 10-1), LAP TGF-beta-1 (β = 0.00; 95% CI: −0.05 to 0.04; P = 8.44 × 10-1), LIF-R (β = -0.04; 95% CI: −0.07 to 0.00; P = 6.67 × 10-2), and TRAIL (β = -0.02; 95% CI: −0.06 to 0.02; P = 3.30 × 10-1). The gene discussed is TGFB1; the disease is colorectal carcinoma.