PDK4, a member of the PDK family, is an enzyme involved in glucose metabolism by regulating the pyruvate dehydrogenase complex (PDC).[69] PDK4 is primarily expressed in tissues with high metabolic activity such as heart.[11] Also, it is linked to diabetes, obesity, and insulin resistance, which are all risk factors of cardiovascular disorders.[70] The extensive research conducted on PDK4 underscores its significance as a potential therapeutic target for addressing these metabolic disorders.[71]. Here, PDK4 is linked to obesity due to melanocortin 4 receptor deficiency.