They also act as either oncogenes or tumor suppressors, altering tumor cell proliferation, invasion, and apoptosis.[85] Researchers have used microRNAs as biomarkers for the diagnosis of different pathologic conditions.[86] For instance, miR-15a modulates coactivator-associated arginine methyltransferase 1 expression, which increases plaque susceptibility.[87]. This evidence concerns the gene CARM1 and neoplasm.