Inflammatory adipocytokines, including retinol-binding protein-4 (RBP4), pentraxin 3 (PTX3), galectin-3 (GAL-3), and plasminogen activator inhibitor (PAI-1), exhibited elevated levels, while anti-inflammatory cytokines netrin-1 (NTN1), interleukin-37 (IL-37), and adiponectin (ADP) showed reduced levels in CAD patients compared to controls. Among these, PTX3 and IL-37 demonstrated the highest sensitivity and specificity, suggesting their potential as robust biomarkers for CAD diagnosis. The gene discussed is LGALS3; the disease is coronary artery disorder.