PDK4 and coronary artery disorder: During chronic inflammation, PDK4 expression rises, which is mediated by the phosphorylation of Jun N-Terminal Kinases.[72] Moreover, regulation of E2F1-dependent PDK4 expression by NF-κB is crucial for maintaining cardiac health.[73] Although PDK4 significantly regulates cardiac energy metabolism, there is no conclusive evidence for a direct link between PDK4 and CAD.