Acute-phase proteins are increased in response to tissue damage, inflammation, infection, and malignancies.[122] Its association with metabolic conditions like dyslipidemia, obesity, hypertension, insulin resistance, and type 2 diabetes has been confirmed previously.[123] Clinically, CRP is widely used for screening organic diseases, assessing disease activity, classification of inflammatory disorders, and controlling infections.[124] CRP levels are stable throughout the day and are not acutely affected by dietary changes. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.