MAPK8 and neoplasm: Malignant cells have been shown to actively eliminate surrounding cells by mechanical cell competition, apoptosis, and engulfment (Levayer et al., 2016; Kohashi et al., 2021), similar to the cell death-mediated elimination of losers during developmental cell competition and EDAC (Maruyama and Fujita, 2017; Parker et al., 2021) Induction of JNK-mediated cell death is also common to developmental competition and tumor cell competition, as shown in intestinal adenomas (Suijkerbuijk et al., 2016).