CELSR3 and colorectal cancer: Evidence is accumulating that a human ortholog of Fmi, CELSR3, is expressed at high levels in a range of solid tumors, including lung, prostate, pancreatic, hepatic, ovarian, and colorectal cancers, and in some cases has been shown to be associated with poor prognosis (Katoh and Katoh, 2007; Erkan et al., 2010; Asad et al., 2014; Goryca et al., 2018; Li et al., 2021; Chen et al., 2021c).