Moreover, the pathology of COVID-19 disease was noticed to be linked to the hyperinflammatory response referred to as a cytokine storm, which is an extreme increase in the circulating levels of pro-inflammatory cytokines including IL-1, IL-2, IL-6, IFN-γ, and TNF-α (a key role player in the cytokine storm), [22, 23], leading to ARDS (acute respiratory distress syndrome), intravascular coagulation, multiorgan failure and eventually death [24]. The gene discussed is TNF; the disease is acute respiratory distress syndrome.