One meta-analysis that involved nine studies of which six (56%) were from Africa showed that, the incidence of cryptococcal meningitis among CrAg positive patients (CD4 count < 200 cells/mm3 and without evidence of cryptococcal meningitis) and received antifungals was 3% compared to 5% among those who did not receive antifungals, equivalent to 40% reduction in the development of cryptococcal meningitis [10]. This evidence concerns the gene CD4 and Cryptococcal meningitis.