AIM2 and medical procedure: Some studies using immunofluorescence analyses have shown that in transient MCAO models, AIM2 co‐localized primarily with microglia and endothelial cells.[57, 58] In contrast to these other studies, our findings demonstrated that AIM2 was expressed primarily in astrocytes and, to a lesser extent, in neuronal cells, microglia, and endothelial cells in the ischemic penumbra at 7 and 14 days after stroke caused by distal middle cerebral artery occlusion, which is a crucial time point for vascular remodeling.