Astrocytes, as constituent cells of the BBB, participate in many vascular remodeling processes and are considered important regulators of vascular remodeling.[8] Recent studies have shown that ischemia can induce two different types of reactive astrocytes, namely, A1‐like (neurotoxic) astrocytes, which are characterized by complement C3, and A2‐like (neuroprotective) astrocytes, which are characterized by S100a10.[22, 23] Our results revealed that, compared with vehicle, 3‐HKA significantly increased the area of astrocyte coverage around microvessels 7 days after stroke (Figure 4a,b). The gene discussed is C3; the disease is stroke disorder.