MMP2 and breast cancer: The PPIN nodes with degree greater than 13 and BC greater than 63.94 were considered hubs, including COL1A1, COL1A2, COL3A1, COL5A1, COL4A1, FN1, COL5A2, MMP2, ITGA2, SPARC, THBS1, and ITGA5.