For example, integrin αvβ3 recognizes and binds to ligands such as fibronectin on the surface of vascular endothelial cells, causing tumor cells to attach to the vessel wall.[77] At the same time, with the help of a vascular endothelial growth factor (VEGF)‐independent approach, tumor cells were able to use host blood vessels to obtain oxygen and nutrients, achieving rapid expansion along the existing blood vessels and forming a local tumor cell population. This evidence concerns the gene FN1 and neoplasm.