VEGFA and neoplasm: On the other hand, inflammatory factors (e.g., interleukin‐1β, tumor necrosis factor‐α) and vasoactive substances (e.g., VEGF itself) released by tumor cells increase vascular permeability, and BBB disruption not only encourage more tumor cells to infiltrate into the blood circulation and enhance metastatic potential, but also promotes the infiltration of peripheral immune cells into the tumor microenvironment, as well as the influx of nutrients, which further contributes to the growth, invasion, and immune evasion of tumors., invasion and immune evasion behavior.