Integrating experimental evidence, we hypothesize that individuals carrying the rs1058588‐C risk allele at the VAMP8 locus have reduced miR‐185 binding affinity at the 3′‐UTR of VAMP8, leading to VAMP8 upregulation; elevated VAMP8 subsequently interacts with DHX9 to promote p65 recruitment to nucleus and the NF‐κB pathway activation, increasing NPC risk (Figure7). The gene discussed is DHX9; the disease is nasopharyngeal carcinoma.