Transcriptome analysis, qRT‐PCR, and western blot assays corroborated that VAMP8 knockdown remarkably downregulated the key NF‐κB target genes, such as CCND1, CDK2, IL1B, MPP1, and MMP9, in NPC cells[12, 13] (Figure 6B,C; and Figures S5C and S9D, Supporting Information). This evidence concerns the gene CCND1 and nasopharyngeal carcinoma.