Consistently with these observations, high expression levels of glucose transporter 1 (GLUT1), hexokinase 1 (HK1), and lactate dehydrogenase A (LDHA) in high-risk GISTs have been reported, likely explaining their glucose-prone metabolism.32 Nevertheless, to our knowledge, the association between [18F]FDG uptake and GIST molecular profiling has not been thoroughly investigated. This evidence concerns the gene HK1 and gastrointestinal stromal tumor.