As expected, the proportion of cases that were HR-positive and ERBB2-negative increased with age, and compared with other racial and ethnic groups, Black females had the highest proportion of HR-negative and ERBB2-negative breast cancer (18.6% [23 213 of 124 560]) followed by Hispanic females (11.3% [16 036 of 141 703]). The gene discussed is ERBB2; the disease is breast carcinoma.