This pattern was generally consistent across racial and ethnic groups, with the exception of Asian or Pacific Islander females younger than 50 years and 50 to 64 years of age and Black females 50 to 64 years of age and 65 years or older whose incidence rates of HR-negative and ERBB2-positive breast cancer remained statistically unchanged from 2010 to 2019. This evidence concerns the gene ERBB2 and breast cancer.