Prior research indicated that tumor cells had the ability to attract macrophages by releasing various cytokines, including CSF‐1, VEGFA, and CCL2.[11, 34] Meanwhile, tumor cells and other cells within the TME could induce a pro‐tumor phenotype in TAMs through the secretion of cytokines such as IL‐4, IL10, and CSF‐1.[11, 35, 36] However, the complexity of the tumor microenvironment and heterogeneity of TAMs contributed to intricate regulatory interactions between tumor cells and macrophages, necessitating further exploration of specific mechanisms. The gene discussed is VEGFA; the disease is neoplasm.