TAMs are the most abundant tumor‐infiltrating immune cells in HCC, and our previous studies indicated the vital role of TAMs in promoting HCC development through facilitating the formation of an immunosuppressive tumor microenvironment.[26, 27] To investigate the impact of TAMs in Gal1‐mediated HCC progression, we utilized clodronate liposomes to deplete macrophages (Figure 1J; Figure S2A, Supporting Information). Here, LGALS1 is linked to hepatocellular carcinoma.