IL4 and neoplasm: Prior research indicated that tumor cells had the ability to attract macrophages by releasing various cytokines, including CSF‐1, VEGFA, and CCL2.[11, 34] Meanwhile, tumor cells and other cells within the TME could induce a pro‐tumor phenotype in TAMs through the secretion of cytokines such as IL‐4, IL10, and CSF‐1.[11, 35, 36] However, the complexity of the tumor microenvironment and heterogeneity of TAMs contributed to intricate regulatory interactions between tumor cells and macrophages, necessitating further exploration of specific mechanisms.