Gal1, an immunosuppressive protein secreted by tumor cells, was implicated in the advancement of various types of cancer, such as breast cancer, melanoma, head and neck cancer, and glioma.[22, 37, 38, 39] It was previously demonstrated that Gal1 was able to facilitate the infiltration of Tregs within the TME, although the precise underlying mechanism remained to be elucidated.[37, 40] Consist with this, we further revealed an association between tumor‐secreted Gal1 and Tregs through analysis of tumor samples obtained from patients with HCC and orthotopic murine models. The gene discussed is LGALS1; the disease is head and neck cancer.