LGALS1 and cancer: Gal1, an immunosuppressive protein secreted by tumor cells, was implicated in the advancement of various types of cancer, such as breast cancer, melanoma, head and neck cancer, and glioma.[22, 37, 38, 39] It was previously demonstrated that Gal1 was able to facilitate the infiltration of Tregs within the TME, although the precise underlying mechanism remained to be elucidated.[37, 40] Consist with this, we further revealed an association between tumor‐secreted Gal1 and Tregs through analysis of tumor samples obtained from patients with HCC and orthotopic murine models.