Astrocytic LRP1 enables mitochondrial transfer to neurons and mitigates ischemic stroke by suppressing ARF1 lactylation in the brain.[28] Heat shock protein A12A (HSPA12A) maintains aerobic glycolytic homeostasis and histone 3 lactylation in cardiomyocytes to attenuate myocardial IRI.[29] Similarly, Du et al. Here, HSPA12A is linked to ischemic stroke.