IFNG and tuberculosis: Similarly, in tuberculosis, macrophages that undergo programmed cell death promote the cytotoxicity of T cells in the immune microenvironment through the release of apoptosis‐related substances, resulting in reduced secretion of IFN‐γ and TNF‐α by T cells.[82] Zbp1‐deficient macrophages significantly reduce the levels of TNF‐α and IFN‐γ secreted by NK cells under LSA stimulation, which was related to the polarization state of the macrophages.