Recent studies have identified Zbp1 as an innate sensor of infections and a target of pathogen evasion strategies in viral infections, parasitic infections, autoimmune diseases, and inflammatory diseases.[21, 22, 23, 24, 25] The molecule is activated by sensing host or viral nucleic acids through the nucleic acid domain to induce apoptosis or necrotic apoptosis in host cells, thereby inhibiting viral replication. Here, ZBP1 is linked to autoimmune disease.