Similarly, in tuberculosis, macrophages that undergo programmed cell death promote the cytotoxicity of T cells in the immune microenvironment through the release of apoptosis‐related substances, resulting in reduced secretion of IFN‐γ and TNF‐α by T cells.[82] Zbp1‐deficient macrophages significantly reduce the levels of TNF‐α and IFN‐γ secreted by NK cells under LSA stimulation, which was related to the polarization state of the macrophages. This evidence concerns the gene TNF and tuberculosis.