This study found that in a degenerative disease model induced by neuroinflammation resulting from AC infection, Zbp1 is highly expressed in macrophages and exerts a pro‐inflammatory effect through the RIP3‐Mlkl axis, Consist with our conclusion, many studies reported that Zbp1 mediated necroptosis via pRIP3‐pMlkl,[28, 70, 71] the Mlkl signaling and necroptosis led to the increase of pro‐inflammatory cytokines in macrophage.[72, 73] Additionally, we noted that related studies have highlighted the potential role of Zbp1 in other neurodegenerative diseases. This evidence concerns the gene ZBP1 and neurodegenerative disease.