As a nucleic acid sensor, Zbp1 is widely involved in the occurrence and progression of pathogen infection, autoimmune diseases, and inflammatory diseases.[24, 25, 26, 27, 28] Zbp1 plays a key antiviral role in macrophages,[29] but whether it mediates the function of macrophages after AC infection is unknown. The gene discussed is ZBP1; the disease is autoimmune disease.