For example, in a neuroinflammation model of Parkinson's disease, Zbp1 plays an anti‐inflammatory role in glial cells and may be involved in regulating cell death.[74] In contrast, in Alzheimer's disease, Zbp1 is upregulated in neurons, promoting neuronal damage, pyroptosis, oxidative stress, and inflammation.[75] These findings suggest that the role of Zbp1 in different neurodegenerative diseases shares certain similarities but also presents differences, indicating that Zbp1's function is context‐dependent, relying on specific disease environments and cell types. Here, ZBP1 is linked to early-onset autosomal dominant Alzheimer disease.