Insulin‐responsive aminopeptidase (IRAP) is a type II transmembrane protein involved in endosome trafficking and immune cell responses.[15, 16, 17] Variants in the IRAP (LNPEP) gene are associated with ischemic stroke and septic shock.[18, 19] IRAP, in addition to its aminopeptidase function, can also bind to cytoskeletal and membrane proteins at its N‐terminal, contributing to the transport and degradation of intracellular endosomes. The gene discussed is LNPEP; the disease is ischemic stroke.