The addition of AD‐PRSnoAPOE and APOE‐RS to a classification model including p‐tau181, age, and sex improved classification accuracy (from 74% to 82%, see Table 2 and Figure 1) and significantly improved model fit (ANOVA P = 0.011, ΔAICc = −4.0), likely due to significant APOE effects. This evidence concerns the gene APOE and Alzheimer disease.