When AD‐PRSnoAPOE, APOE‐RS, and p‐tau181 were included in the classification model together, all remained significantly associated with MCI+/AD, there was a modest improvement in classification accuracy (see Table 2 and Figure 1) and model fit significantly improved compared to the polygenic risk model (ANOVA P < 0.001, ΔAICc =  −8.7) and p‐tau181 model (ANOVA P = 0.020, ΔAICc = −3.2). This evidence concerns the gene APOE and Alzheimer disease.