APOE and Alzheimer disease: Using AD‐PRSnoAPOE, APOE‐RS, and p‐tau181 together, there was an improvement in classification accuracy (Table 2 and Figure 1) and significant improvement in model fit compared to the polygenic risk model (ANOVA P = 0.027, ΔAICc = −2), and p‐tau181 model (ANOVA P = 0.026, ΔAICc = −3).