Although the impact of targeting p21‐positive senescent cells in OA has not been previously reported, studies have shown that selectively eliminating p21‐positive cells offers better specificity in clearing senescent cells and has demonstrated efficacy in alleviating osteoporosis.[22, 35] In our experiment, we successfully generated p21‐3MR mice to selectively eliminate p21‐positive senescent cells, which resulted in a mitigated progression of OA. The gene discussed is CDKN1A; the disease is osteoporosis.