The ACSL1 gene is a NETosis‐related gene in chronic inflammation or autoimmune diseases.[23] Despite THP1 monocyte cell lines stably overexpressing ACSL1 exhibiting a pronounced tendency toward osteoclast differentiation (Figure S10a, Supporting Information), we observed that oxLDL at high concentrations (100 μg mL−1), while markedly promoting ACSL1 overexpression, did not significantly increase their inflammatory phenotype (Figure S10b–e, Supporting Information), suggesting an alternative mechanism by which they might promote NET formation. Here, ACSL1 is linked to autoimmune disease.