Previous studies have shown that phytomelatonin affects the transport and signal transduction of auxin, as well as the accumulation of auxin, through the NO signaling pathway to regulate the formation of ARs.[10, 11] With the discovery of phytomelatonin receptors, it is unclear whether the effect of phytomelatonin on AR induction is achieved through its receptors. The gene discussed is AR; the disease is Axenfeld-Rieger syndrome.