SERPING1 exhibited downregulation in the majority of cancer types, such as colorectal cancer (COAD), lung squamous cell carcinoma (LUSC), lung adenocarcinoma (LUAD), and HCC, whereas it was increased in select malignancies, notably renal clear cell carcinoma (KIRC) (Figure 3F). The gene discussed is SERPING1; the disease is colorectal cancer.