Tang et al. [110] demonstrated that MSC-EXOs loading with antisense oligonucleotide (EXOs-ASO) and siRNA (EXOs-siRNA) targeting STAT3 via electroporation reduced both STAT3 levels and ECM deposition as well as enhanced liver functions and inhibited fibrosis in an experimental model of CCl4-induced liver fibrosis. The gene discussed is STAT3; the disease is Hepatic fibrosis.