Similarly, EXOs with overexpressed miR-181b from adipose MSCs were demonstrated to upsurge autophagy and diminish TGF-β1-induced hepatic fibrosis by inhibiting STAT3/proapoptotic proteins B-cell lymphoma-2/Beclin 1 axis in mouse hepatic stellate (HST-T6 ) cells in vitro and CCl4-induced hepatic fibrosis in vivo [95]. This evidence concerns the gene BECN1 and Hepatic fibrosis.