IGF1 and Hepatic fibrosis: Fiore et al. [99]used an adenoviral transfection system to transfect human insulin growth factor like-I (IGF-I) into human umbilical cord perivascular cells and found that IGF-I-MSC-EVs exhibited more anti-fibrotic effects in thioacetamide-induced liver fibrosis than EVs-depleted conditioned medium.