Specifically, miR-148a released from human umbilical cord MSC-EXOs was shown to regulate intrahepatic macrophage via remodelling of pro-inflammatory macrophage phenotypes, controlling Kruppel-like factor 6/ signal transducer and activator of transcription 3 (STAT3) activity and, consequently, inhibiting liver fibrosis progression [73]. Here, STAT3 is linked to Hepatic fibrosis.