CD274 and non-small cell lung carcinoma: In patients with NSCLC expressing PD-L1 TPS ≥ 50%, the ORR tended to be higher in the HMGB1high group than that in the HMGB1low group (60.0% vs. 22.2%, p = 0.06; Fig. 3b); however, there was no significant difference in ORR between the HMGB1high and HMGB1low groups in patients with NSCLC expressing PD-L1 TPS < 50% or unknown (29.3% vs. 16.2%, p = 0.17; Fig. 3c).