TLR7 and Splenomegaly: In Slc29a3−/− mice, lysosomal nucleoside stress activates TLR7, leading to splenomegaly, whereas lysosomal RNA stress in Rnaset2−/− mice results in both hepatomegaly and splenomegaly (Kettwig et al., 2021), suggesting that RNA stress activate distinct responses compared with nucleoside stress.