HIV-1G89V CA was insensitive to all TRIM-Cyp fusions as expected (Fig. S4), and the ability of MX2 to enhance HIV-1G89V CA infection was unaffected in any of the RANBP2 point mutant cell lines (Fig. 3E), further indicating that the reduction in MX2 enhancement of HIV-1G89V CA infection in RANBP2∆Cyp cells (Fig. 2B) is the result of CA-independent effects. Here, PPIG is linked to infection.