Notably, although the ability of MX2 to restrict HIV-1 infection is reduced in CypA−/− and RANBP2∆Cyp cells (44) (Fig. 2), we found that the effect of MX2 on integration targeting was maintained in the absence of CA-Cyp interactions (Fig. 4B, D, and E). The gene discussed is MX2; the disease is HIV-1 infection.