Notably, while the antiviral activity of MX2 against HIV-1WT was reduced in control cells upon depletion of the cytoplasmic ring Nups, NUP88, NUP214, and RAE1 and upon depletion of NUP153, MX2 expression enhanced HIV-1WT infection upon these knockdowns in RANBP2∆Cyp cells, similar to its effect on HIV-1G89V CA in both control and RANBP2∆Cyp cells (Fig. 5B through E). Here, MX2 is linked to infection.