IKBKG and hepatocellular carcinoma: Due to the robust ISG induction mounted upon HAV infection, we aimed to revisit NEMO cleavage by 3C and its impact on the host’s innate immune and inflammatory responses in more authentic liver-derived models, including HCC-derived Huh7 and HepG2 cells, both permissive for HAV infection, and immortalized, non-neoplastic PH5CH hepatocytes.