In summary, we hypothesize that BPS induces lipid metabolism disorders in HepG2 and SK-Hep-1 cells through oxidative stress by the following pathway: increased ROS and MDA content induces oxidative stress in cells, which directly or indirectly inhibits the expression of PPARα to regulate the expression of CPT1B, CD36, SREBPC, and FASN, and thus the cells undergo a disturbance in cholesterol metabolism, ultimately leading to cellular lipid accumulation. Here, PPARA is linked to Disorder of lipid metabolism.