In addition to hypertension potentially exacerbating the decline of TREM2 in mice after Pb exposure, the TREM2 protein expression following co-exposure to hypertension and Pb showed the most significant decline speed at 12 w exposure in the PFC, hippocampus, and hypothalamus compared to that at other exposure time points (Figure 2C). Here, TREM2 is linked to hypertensive disorder.