The results in vivo showed that the expression of TREM2 protein of the PFC in hypertensive mice after Pb exposure decreased at 4 w exposure, while the expression of the TREM2 protein in the hippocampus and hypothalamus decreased at 8 w, with both of them only exerted in the Pb + hypertension group. The gene discussed is TREM2; the disease is hypertensive disorder.