To identify the inflammatory status along with Pb treatment, the protein expression of proinflammatory cytokines (IL-6 and TNF-α) in hypertensive mice after Pb exposure was detected in prefrontal cortex (PFC), hippocampus, and the hypothalamus of mice with/without hypertension and Pb exposure for 2 w, 4 w, 8 w, 12 w, and 24 w. This evidence concerns the gene IL6 and hypertensive disorder.