Since the increase in the protein levels of CYP1A1, a representative target gene of AhR, peaked 6 h after indoxyl sulfate stimulation [48], we also measured the transcriptional activity of AhR at the same stimulation time after pretreatment of HCT-116 CRC cells with MK2206. This evidence concerns the gene CYP1A1 and colorectal carcinoma.