TNF and Alzheimer disease: These cytokine cocktails include the Th2-type IL-4 and IL-13, the Th1-type interferon γ (IFN-γ) and tumor necrosis factor α (TNF-α), and the Th17-type IL-17, which have been reported to be involved in skin inflammation related to human AD or psoriasis [5,6,7,8].