Diverse tumor or tumor stroma antigens have been targeted with the IL-2 immunocytokine, including the carcinoembryonic antigen (CEA), CD20, CD30, disialoganglioside 2 (GD2), epithelial cell adhesion molecule (EpCAM), fibroblast activation protein α(FAP), and extracellular matrix (ECM) proteins preferentially expressed in the tumor vasculature, such as extra domain A of fibronectin (A-FN), extra domain B of fibronectin (B-FN), and tenascin-C. This evidence concerns the gene TNFRSF8 and neoplasm.