TLR2 and Lyme disease: Toll-like receptor 2 (TLR2) plays a crucial role in the immune response to the outer-surface lipoprotein A (OspA) of B. burgdorferi, the causative agent of Lyme disease, by recognizing tripalmitoyl-S-glyceryl-cysteine (Pam3Cys)-modified lipoproteins.