Cationic or ionizable cationic lipids and PEGylated lipids of the mRNA-LNP-COVID19 vaccine can also induce acute inflammatory syndrome by increasing the secretion of cytokines, including IL-1α, IFN-γ, IL-1β, and IL-8 by activating the complement system [34,36,37]. This evidence concerns the gene IL1A and COVID-19.