Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8), as well as platelet agonists like thrombin and ADP, present in the tumor microenvironment, promote platelet autophagy, resulting in platelet activation [34]. This evidence concerns the gene IL6 and neoplasm.