Tumor-associated humoral factors and cytokines, including granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-1 (IL-1), and thrombopoietin (TPO), influence the formation of tumor-associated platelets [35,36,37,38,39]. This evidence concerns the gene THPO and neoplasm.