Novel chemical and genetic intervention strategies utilizing ‘epidrugs’ and epigenomic editing aimed at histone modifiers such as Ipl1 (Aurora B kinase), Nop1 (Fibrillarin), and p300/CBP could potentially improve cell survival in the context of neurodegenerative disease [28,100,101,102,103,104,105]. Here, EP300 is linked to neurodegenerative disease.